A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins
Won Il Choi1, Nazila Kamaly, Lorena Riol-Blanco
1Laboratory of Nanomedicine and Biomaterials, Department of Anesthesiology, Brigham and Women's Hospital and ‡Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School , Boston, Massachusetts 02115, United States.
Abstract:
Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.
