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Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.3K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
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Histone Modification02:32

Histone Modification

14.3K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
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Histone Modification02:32

Histone Modification

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4.0K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
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Related Experiment Video

Updated: Apr 21, 2026

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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Epigenetic modifications in prostate cancer.

Marjolaine Ngollo1, Aslihan Dagdemir, Seher Karsli-Ceppioglu

  • 1Department of Oncogenetics, Centre Jean Perrin, CBRV, 28 place Henri Dunant, BP 38, 63001 Clermont-Ferrand, France.

Epigenomics
|October 22, 2014
PubMed
Summary
This summary is machine-generated.

Epigenetic modifications significantly impact prostate cancer development. This review highlights epigenetic mechanisms and potential therapeutic targets, including DNA methylation and histone modifications, for cancer treatment.

Keywords:
DNA methylationepigenetic modificationshistone methylationmicroRNAprostate cancer

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Prostate cancer is a leading cause of cancer death in men.
  • Epigenetic modifications, including DNA methylation, histone modifications, and microRNA expression, play a crucial role in prostate cancer development and progression.
  • Understanding these epigenetic events is vital for advancing prostate cancer research.

Purpose of the Study:

  • To review the epigenetic mechanisms involved in prostate cancer.
  • To emphasize pharmacologic epigenetic target agents for potential therapeutic strategies.
  • To highlight the need for further research into enzyme interactions and transcriptional regulation in prostate cancer.

Main Methods:

  • Literature review of epigenetic mechanisms in prostate cancer.
  • Summary of epigenetic changes and their role in gene regulation.
  • Focus on pharmacologic agents targeting epigenetic modifications.

Main Results:

  • Epigenetic modifications are key drivers in prostate cancer.
  • Epigenetic drugs targeting DNA methylation and histone modifications show potential for reactivating silenced genes.
  • Further research is needed to understand the complex interactions of epigenetic enzymes.

Conclusions:

  • Epigenetic alterations are fundamental to prostate cancer.
  • Targeting epigenetic mechanisms offers promising therapeutic avenues.
  • Continued investigation into epigenetic pathways is a priority for prostate cancer research and treatment.