Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sleep in the Down syndrome.

H Hamaguchi1, T Hashimoto, K Mori

  • 1Department of Pediatrics, School of Medicine, University of Tokushima, Japan.

Brain & Development
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic and environmental factors affecting peak bone mass in premenopausal Japanese women.

Environmental health and preventive medicine·2011
Same author

"Dropped head syndrome" caused by Lambert-Eaton myasthenic syndrome.

Muscle & nerve·2009
Same author

Treatment of adult AML with t(6;11)(q27;q23) by allogeneic hematopoietic SCT in the first CR.

Bone marrow transplantation·2008
Same author

In vivo measurement of human dermis by 1064 nm-excited fiber Raman spectroscopy.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·2008
Same author

Discovery of metaflumizone, a novel semicarbazone insecticide.

Veterinary parasitology·2007
Same author

Improving symptoms of senile dementia by a night-time spa bathing.

Archives of gerontology and geriatrics·2004
Same journal

Association of relative age with medical consultations for developmental concerns: A nationwide birth cohort study in Japan.

Brain & development·2026
Same journal

Extending the combined N-back/Nogo paradigm: Toward subtype-sensitive and translationally meaningful ERP research in ADHD.

Brain & development·2026
Same journal

Receptor-specific dopaminergic imbalance and sensory gating in Lesch-Nyhan syndrome.

Brain & development·2026
Same journal

From weather stations to the home environment: Refining seizure prediction in pediatric drug-resistant epilepsy.

Brain & development·2026
Same journal

Pediatric GBS-myelitis overlap syndrome: Severe phenotype, treatment response, and neurological outcomes.

Brain & development·2026
Same journal

Aspartoacylase (ASPA) gene mutations and neuroimaging features in Iranian patients with Canavan disease: a descriptive study.

Brain & development·2026
See all related articles

Children with Down syndrome (DS) exhibit distinct sleep patterns, including increased body movements and altered REM sleep intervals compared to neurotypical children. These findings highlight potential sleep disturbances in young DS patients.

Area of Science:

  • Pediatric Sleep Medicine
  • Neurodevelopmental Disorders
  • Genetics

Background:

  • Down syndrome (DS) is a genetic disorder associated with various health complications, including potential sleep abnormalities.
  • Understanding sleep characteristics in young children with DS is crucial for early intervention and management.

Purpose of the Study:

  • To investigate and characterize the sleep patterns of young children diagnosed with Down syndrome.
  • To compare sleep parameters between children with DS and age-matched neurotypical controls.

Main Methods:

  • Polysomnography was used to record sleep in 10 children with DS (9 months to 7 years) and 16 controls.
  • Analysis included sleep stage percentages, rapid eye movements (REMs)/min, REM interval (I)/min, awakenings, body movements (BMs), and twitch movements (TMs).

Related Experiment Videos

Main Results:

  • Children with DS showed increased REMs/min and shorter REM intervals (I < 1 sec) in the 1-5 year age group compared to controls (p<0.05).
  • Increased frequency of body movements (BMs) during total sleep (p<0.01) and abnormal BM patterns were observed in DS patients.
  • Twitch movements (TMs) were less frequent in DS children (p<0.05), with abnormal TM patterns noted in several cases.

Conclusions:

  • Young children with Down syndrome exhibit significant differences in sleep architecture and movement patterns compared to controls.
  • Sleep disturbances, including increased awakenings and altered movement frequencies, are prevalent in this population.
  • Further research is warranted to explore the clinical implications of these sleep findings in DS.