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[Left ventricule function and sickle-cell anemia. Echocardiographic study].

G Estrade1, O Poitrineau, F Bernasconi

  • 1Service de cardiologie, centre hospitalier régional de Fort-de-France.

Archives Des Maladies Du Coeur Et Des Vaisseaux
|December 1, 1989
PubMed
Summary
This summary is machine-generated.

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Patients with sickle cell disease (SS) show enlarged cardiac chambers and increased cardiac output, indicative of an "anemic heart." This contrasts with normal subjects, highlighting significant cardiovascular changes in SS disease.

Area of Science:

  • Cardiology
  • Hematology
  • Medical Imaging

Context:

  • Sickle cell disease (SS) is a genetic blood disorder with known systemic complications.
  • Cardiac involvement in SS disease is increasingly recognized but requires detailed characterization.
  • Echocardiography is a key non-invasive tool for assessing cardiac structure and function.

Purpose:

  • To investigate cardiac chamber dimensions and left ventricular function in patients with homozygous sickle cell disease (SS) and sickle cell trait (AS, SC, BS).
  • To compare echocardiographic parameters between SS disease patients, sickle cell trait patients, and healthy controls.
  • To identify specific cardiac adaptations and potential pathologies associated with SS disease.

Summary:

  • Echocardiography revealed significantly larger left atrial, left ventricular, and right ventricular dimensions in SS disease patients compared to controls.

Related Experiment Videos

  • Patients with SS disease exhibited higher indexed myocardial surfaces, increased end-diastolic left ventricular volumes, and elevated cardiac index and stroke volume.
  • Peripheral resistances were lower in SS disease patients, and velocities of circumferential fiber shortening were reduced, consistent with an "anemic heart" phenotype in two-thirds of patients.

    • Impact:

    • Findings demonstrate significant cardiac remodeling and altered hemodynamics in sickle cell disease, contributing to the understanding of its cardiovascular burden.
    • The identification of an "anemic heart" phenotype in a majority of SS patients underscores the need for cardiac monitoring and management.
    • This study provides valuable echocardiographic data that can inform clinical practice and future research on cardiovascular complications in sickle cell disease.