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[Testing of a hyperimmune serum in calves infected intranasally with Mycoplasma bovis]
Mycoplasma (M.) bovis hyperimmune serum was subcutaneously injected to 16 of 26 calves repeatedly intranasally infected with M. bovis, during and/or after experimental infection. Antibody titres between 1:32 and 1:256 were recorded by means of indirect haemagglutination from the calves treated. Transmission of film-inhibitory antibodies failed to work. Neither clinical manifestations nor pathologico-anatomic alterations to the lungs of experimentally infected animals were mitigated by hyperimmune serum treatment. M. bovis, in high germ counts, was re-isolated from nasal swabs, trachea, pulmonary lymph nodes, and inflammatory lung tissue of both treated and untreated calves.
Mycoplasma (M.) bovis hyperimmune serum was subcutaneously injected to 16 of 26 calves repeatedly intranasally infected with M. bovis, during and/or after experimental infection. Antibody titres between 1:32 and 1:256 were recorded by means of indirect haemagglutination from the calves treated. Transmission of film-inhibitory antibodies failed to work. Neither clinical manifestations nor pathologico-anatomic alterations to the lungs of experimentally infected animals were mitigated by hyperimmune serum treatment. M. bovis, in high germ counts, was re-isolated from nasal swabs, trachea, pulmonary lymph nodes, and inflammatory lung tissue of both treated and untreated calves.