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Updated: Apr 21, 2026

Light-driven Enzymatic Decarboxylation
Published on: May 22, 2016
Unlocking the pH-responsive degradability of fumaramic acid derivatives using photoisomerization
Wonmin Choi1, Sunyoung Kang, Yeongbong Mok
1Department of Chemistry, College of Natural Sciences, Seoul National University, Gwanak-ro 1, Gwanak-gu, Seoul 151-747 (Republic of Korea).
Abstract:
Fumaramic acid derivatives can be converted into their cis isomer maleamic acid derivatives under UV illumination, and these maleamic acid derivatives show pH-responsive degradability at acidic pH only after the preceding photoisomerization. The rate of the tandem photoisomerization-degradation of fumaramic acid derivatives can be finely controlled by changing the substituents on the double bond. Photoisomerization-based unlocking of the pH-responsive degradability of fumaramic acid derivatives has strong potential for the development of multisignal-responsive smart materials in biomedical applications.
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