Related Experiment Video

Updated: Aug 11, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

[Lipoprotein Lp(a): a risk factor for atherosclerosis]

J A Gutiérrez Fuentes, J J Gutiérrez Yago, E Díez Monedero

    Medicina Clinica
    |November 11, 1989
    PubMed

    Insights

    Elevated lipoprotein Lp(a) levels indicate vascular risk, particularly in younger individuals. Higher Lp(a) cholesterol concentrations correlate with an increased incidence of myocardial infarction.

    Area of Science:

    • Cardiovascular Medicine
    • Lipidology
    • Clinical Research

    Context:

    • Coronary atherosclerosis is a significant health concern.
    • Lipoprotein Lp(a) is implicated in cardiovascular disease development.
    • Understanding risk factors for acute myocardial infarction is crucial.

    Purpose:

    • To investigate the role of lipoprotein Lp(a) in the development of coronary atherosclerosis.
    • To determine if lipoprotein Lp(a) is a risk factor for acute myocardial infarction.
    • To analyze the association between Lp(a) cholesterol levels and cardiovascular events.

    Summary:

    • A study of 185 patients with coronary atherosclerosis and acute myocardial infarction compared them to a control group.
    • Lipoprotein Lp(a) was found to indicate vascular risk, especially in younger age groups (40-60 years).
    • A higher incidence of myocardial infarction was observed in individuals with Lp(a) cholesterol levels exceeding 50 mg/dl.

    Impact:

    • This research highlights lipoprotein Lp(a) as a key indicator of vascular risk.
    • Findings suggest Lp(a) cholesterol levels should be considered in cardiovascular risk assessment.
    • The study provides evidence supporting Lp(a) as a risk factor for acute myocardial infarction, particularly in specific demographics.

    More Related Videos

    Quantification of Atherosclerosis in Mice06:59

    Quantification of Atherosclerosis in Mice

    Published on: June 12, 2019

    Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation06:47

    Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

    Published on: January 28, 2021

    Related Concept Videos

    Inflammation01:38

    Inflammation

    Overview
    Cholesterol: Significance and Regulation01:29

    Cholesterol: Significance and Regulation

    Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
    Considering cholesterol and...
    Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

    Blood Studies for Cardiovascular System III: Serum Lipid Profile

    Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
    Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
    Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
    Atherosclerosis I: Introduction01:30

    Atherosclerosis I: Introduction

    Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
    Atherosclerosis III: Management01:26

    Atherosclerosis III: Management

    Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
    Peripheral Artery Disease I: Introduction01:30

    Peripheral Artery Disease I: Introduction

    Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...