Related Experiment Video
Updated: Apr 21, 2026

Development of Recombinant Proteins to Treat Chronic Pain
Published on: April 11, 2018
Programmable intrathecal pumps for the management of chronic pain: recommendations for improved efficiency
1Department of Anesthesiology and Pain Medicine, University of Texas Medical Branch, Galveston, TX, USA.
Abstract:
The management of chronic pain can be very challenging. Often, physicians employ intrathecal (IT) drug delivery systems as a last resort to relieve intractable pain. The system consists of an implantable pump that stores and delivers medication through a catheter to the IT space. Programmability is achieved by positioning an external devise over the implanted pump to change the mode of drug delivery. The innovations in programmable IT drug delivery systems are expanding more rapidly than ever before. Unfortunately, the rapid expansion is accompanied by a lack of prospective randomized trials examining these new options. In an effort to improve results and reduce side effects, publications by experts or expert consensus panels provide guidance for the community. The purpose of this article is to provide a summary of high interest topics in recent publications.
Related Concept Videos
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Analgesia and Pain Management
Local Anesthetics: Clinical Application as Epidural Anesthesia
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Modified-Release Drug Delivery Systems: Rate-Programmed II
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices
Opioid Analgesics: Synthetic and Semisynthetic Opioids

