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LSF expression and its prognostic implication in colorectal cancer.

Hui Jiang1, Jun Du1, Jianqiang Jin2

  • 1Department of General Surgery, The Affiliated Hospital of Jiangnan University 200 Huihe Road, Wuxi 214062, China ; Department of General Surgery, The 4th People's Hospital of Wuxi 200 Huihe Road, Wuxi 214062, China.

International Journal of Clinical and Experimental Pathology
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Summary

Liver-specific factor (LSF) is upregulated in colorectal cancer (CRC), correlating with advanced disease and poor prognosis. High LSF expression indicates a need for targeted therapies and better prognostic prediction in CRC patients.

Keywords:
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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer death globally, with therapy failure being a primary driver.
  • Liver-specific factor (LSF), a transcription factor involved in angiogenesis, invasion, and proliferation, is implicated in chemoresistance.
  • Understanding LSF's role is crucial for improving CRC treatment outcomes.

Purpose of the Study:

  • To investigate the expression levels of LSF in colorectal cancer tissues.
  • To determine the correlation between LSF expression and clinicopathological features of CRC.
  • To evaluate the prognostic value of LSF expression in CRC patients.

Main Methods:

  • Real-time PCR and Western blot were used to analyze LSF mRNA and protein expression in 23 paired CRC samples.
  • Immunohistochemistry was employed to assess LSF protein expression in 166 paired CRC samples.
  • Statistical analysis correlated LSF expression with tumor size, stage, and patient survival.

Main Results:

  • LSF mRNA and protein were significantly upregulated in colorectal cancer tissues compared to normal tissues.
  • High LSF expression correlated with larger tumor size, advanced pN and AJCC stages, and a higher Ki-67 proliferation index (P < 0.001).
  • Patients with high LSF expression exhibited significantly worse 5-year survival rates (39.6%) and shorter median overall survival (34 months) compared to those with low LSF expression (78.6% and 57 months, respectively).

Conclusions:

  • LSF is a key mediator in colorectal cancer tumorigenesis and progression.
  • LSF expression serves as a significant biomarker for predicting prognosis in CRC patients.
  • Targeting LSF may offer a potential therapeutic strategy for improving outcomes in colorectal cancer.