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Thyroid cancer in systemic lupus erythematosus: a meta analysis
Min Zhang1, Xiao-Mei Li1, Guo-Sheng Wang1
1Department of Rheumatology and Immunology, Anhui Provincial Hospital, Anhui Medical University Hefei 230001, P. R. China.
International Journal of Clinical and Experimental Pathology
|October 23, 2014
Summary
This study found that individuals with systemic lupus erythematosus (SLE) have a significantly increased risk of developing thyroid cancer. The meta-analysis confirmed a positive association, highlighting a heightened risk for SLE patients.
Area of Science:
- Rheumatology
- Oncology
- Epidemiology
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with complex manifestations.
- Previous research on the association between SLE and thyroid cancer risk has yielded inconclusive and heterogeneous results.
- A quantitative synthesis is necessary to clarify the potential link between SLE and thyroid cancer.
Purpose of the Study:
- To quantitatively investigate the risk of thyroid cancer in patients with systemic lupus erythematosus (SLE).
- To perform a systematic review and meta-analysis to consolidate existing evidence on SLE and thyroid cancer.
- To provide a clearer understanding of the association between SLE and the risk of developing thyroid cancer.
Main Methods:
- A systematic literature search was conducted using the PubMed electronic database.
- Studies characterizing the associated risk of thyroid cancer in SLE patients were included.
- Standardized incidence rates (SIRs) with 95% confidence intervals (CIs) were meta-analyzed using a fixed-effect model.
Main Results:
- Seven cohort studies met the inclusion criteria for the meta-analysis.
- The pooled SIR for thyroid cancer in SLE patients was 2.22 (95% CI: 2.11-2.34), indicating a significantly increased risk.
- Homogeneity was confirmed across the included studies, and sensitivity analyses supported the robustness of the findings.
Conclusions:
- This meta-analysis reveals a significant positive association between systemic lupus erythematosus (SLE) and an increased risk of thyroid cancer.
- Individuals diagnosed with SLE exhibit a heightened susceptibility to developing thyroid cancer.
- The findings underscore the importance of considering thyroid cancer surveillance in patients with SLE.
