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Congenital insensitivity to pain with anhidrosis in an Iranian patient
Nasrollah Saleh-Gohari1, Marzye Mohammadi-Anaie2
1Genetic Department, Medical School, Kerman University of Medical Sciences, Kerman, Iran.
Basic and Clinical Neuroscience
|October 23, 2014
Abstract:
Congenital insensitivity to pain with anhidrosis is a rare disease of the nervous system which causes one to lose his/her feeling of pain. The disease is subtype four of hereditary sensory and autonomic neuropathy (HSAN IV) that results from NTRK1 gene defect. Direct sequencing was performed to screen NTRK1 for mutations. The result revealed a homozygous deletion of adenine on intron 14 that may cause the disease.

