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Updated: Apr 21, 2026
Updated Technique for Reliable, Easy, and Tolerated Transcranial Electrical Stimulation Including Transcranial Direct Current Stimulation
Published on: January 3, 2020
Methodological dimensions of transcranial brain stimulation with the electrical current in human
Maryam Rostami1, Mehrshad Golesorkhi2, Hamed Ekhtiari3
1Translational Neuroscience Program, Institute for Cognitive Science Studies, Tehran, Iran ; Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.
Transcranial current stimulation (TCS) offers a safe, noninvasive neuromodulation technique to alter brain excitability for functional brain mapping and treating neuropsychiatric disorders. This method presents advantages over other brain stimulation modalities.
Area of Science:
- Neuroscience
- Neuromodulation
- Neurotechnology
Background:
- Transcranial current stimulation (TCS) is a neuromodulation technique using mild electrical currents (1-2 mA) to modulate brain excitability.
- This method offers potential for functional human brain mapping with causal inferences and treatment of neuropsychiatric disorders due to its safety, simplicity, and noninvasive nature.
Purpose of the Study:
- To compare Transcranial current stimulation (TCS) with other brain stimulation modalities, highlighting its advantages.
- To detail methodological considerations for applying TCS in basic and clinical neuroscience research in human subjects.
- To discuss technical aspects and safety of TCS devices and accessories.
Main Methods:
- Review and comparison of Transcranial current stimulation (TCS) with existing brain stimulation techniques.
- Detailed explanation of methodological procedures for implementing TCS in human neuroscience studies.
- Articulation of technical specifications and safety considerations for TCS devices.
Main Results:
- Transcranial current stimulation (TCS) demonstrates potential advantages in cost, simplicity, safety, and semi-focal effects compared to other modalities.
- Methodological guidelines for effective and safe application of TCS in research settings are provided.
- Key technical and safety features of TCS equipment are outlined.
Conclusions:
- Transcranial current stimulation (TCS) is a promising neuromodulation tool with significant potential in basic neuroscience, clinical applications, and future therapeutic interventions.
- The study emphasizes the practical aspects, safety, and comparative benefits of TCS for researchers and clinicians.
