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Ecstasy-induced caspase expression alters following ginger treatment
Sara Soleimani Asl1, Bagher Pourheydar2, Fataneh Dabaghian3
1Research Center for Behavioral Disorders and Substance Abuse, Hamadan University of Medical Sciences, Hamadan, Iran ; Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Introduction:
Exposure to 3-4, methylenedioxymethamphetamine (MDMA) leads to cell death. Herein, we studied the protective effects of ginger on MDMA- induced apoptosis.
Methods:
15 Sprague dawley male rats were administrated with 0, 10 mg/kg MDMA, or MDMA along with 100mg/kg ginger, IP for 7 days. Brains were removed to study the caspase 3, 8, and 9 expressions in the hippocampus by RT-PCR. Data was analyzed by SPSS 16 software using the one-way ANOVA test.
Results:
MDMA treatment resulted in a significant increase in caspase 3, 8, and 9 as compared to the sham group (p < 0.001). Ginger administration however, appeared to significantly decrease the same (p < 0.001).
Discussion:
Our findings suggest that ginger consumption may lead to the improvement of MDMA-induced neurotoxicity.
