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A Generalized Method for Determining Free Soluble Phenolic Acid Composition and Antioxidant Capacity of Cereals and Legumes

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Published on: June 10, 2022

New Phenolics from Linum mucronatum subsp. orientale.

Khadijeh Zare¹, Ali Movafeghi², Sayed Abolghasem Mohammadi³

¹Department of Plant Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran ; Research Center for Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Bioimpacts : BI

|October 23, 2014

Summary

This study identified new lignans and flavonoids from Linum mucronatum subsp. orientale. These compounds, including 6-MeO-α-peltatin, are significant for potential chemotherapy drug development.

Keywords:

6-MeO-α- peltatin Flavonoids Lignan Linum mucronatum Mucronasides

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Published on: March 9, 2021

Area of Science:

Phytochemistry
Natural Products Chemistry
Medicinal Botany

Background:

Lignans and flavonoids are key plant phenolics.
Aryltetralin lignans from Linum species are vital for chemotherapy drug synthesis.
Linum mucronatum subsp. orientale is a source of these important compounds.

Purpose of the Study:

To isolate and identify lignans and flavonoid glycosides from the aerial parts of Linum mucronatum subsp. orientale.
To investigate the phytochemical profile of L. mucronatum subsp. orientale.

Main Methods:

Phytochemical analysis of Hexane, Dichloromethane (DCM), and Methanol (MeOH) extracts.
Separation and purification using various chromatography techniques (CC, prep-TLC, GC/MS, HPLC).
Structure elucidation via co-chromatography, HPLC, and Nuclear Magnetic Resonance (NMR) spectroscopy.

Main Results:

Podophyllotoxin and a new compound, 6-MeO-α-peltatin, identified as major lignans in the DCM extract.
Two novel flavonoid glycosides discovered in the methanolic extract.
Confirmation of aryltetralin-type lignans and flavonoids in L. mucronatum extracts.

Conclusions:

The study successfully isolated and identified significant lignans and flavonoids from L. mucronatum subsp. orientale.
The findings report the first occurrence of 6-MeO-α-peltatin and flavonoids in this specific plant species.
These identified compounds hold potential for future pharmaceutical applications, particularly in chemotherapy.