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Novel BODIPY-based fluorescence turn-on sensor for Fe3+ and its bioimaging application in living cells
Binglin Sui1, Simon Tang, Taihong Liu
1Department of Chemistry and ‡CREOL, The College of Optics and Photonics, University of Central Florida , Orlando, Florida 32816, United States.
Abstract:
A novel boron-dipyrromethene (BODIPY) based fluorescence turn-on sensor for detecting Fe(3+) in aqueous media is reported with 23-fold fluorescence enhancement. The sensor is comprised of a combination of BODIPY fluorophore and a new Fe(3+)-recognizing cryptand that exhibits high selectivity, sensitivity, and reversibility toward Fe(3+) detection. Cell imaging studies demonstrate that this sensor is capable of sensing Fe(3+) in living cells.
