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Cognition in a multiple system atrophy series of cases from Argentina
Emilia Gatto1, Ignacio Demey2, Ana Sanguinetti1
1Department of Movement Disorders, Instituto Neurociencias de Buenos Aires, Buenos Aires, Argentina.
Unlabelled:
Cognitive dysfunction may occur in 17-40% of patients with multiple system atrophy (MSA). It has been suggested a milder cognitive impairment in cerebellar (MSA-C) than in parkinsonian variant (MSA-P). However, differences in cognitive profiles remain under discussion.
Objective:
To evaluate cognitive features in a series of patients with "probable MSA" from Argentina.
Method:
After informed consent was obtained, an extensive cognitive tests battery was administered. Nine patients (6 MSA-P and 3 MSA-C) composed the sample.
Results:
Depression was detected in 43% of patients. Seven patients showed at least one cognitive domain impairment. Temporospatial orientation, visuospatial abilities, executive and attentional functions, episodic memory and language were compromised in MSA-P, while MSA-C dysfunction was restricted to attentional and executive domains.
Conclusion:
Despite the small sample size, our findings could suggest a more widespread cognitive impairment in MSA-P than MSA-C.
