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Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
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A High-content Assay for Monitoring AMPA Receptor Trafficking

A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

Interaction proteomics reveals brain region-specific AMPA receptor complexes.

Ning Chen¹, Nikhil J Pandya, Frank Koopmans

¹Department of Molecular and Cellular Neurobiology, and ‡Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University , De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands.

Journal of Proteome Research

|October 23, 2014

Summary

AMPA receptor auxiliary proteins form unique brain region-specific complexes, influencing glutamate signaling. These interactions may explain differential regulation of AMPA receptor functions across brain areas.

Keywords:

AMPA receptor brain protein complex proteomics synapse

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Last Updated: Apr 21, 2026

A High-content Assay for Monitoring AMPA Receptor Trafficking

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Published on: January 28, 2019

$Combined Optogenetic and Freeze-fracture Replica Immunolabeling to Examine Input-specific Arrangement of Glutamate Receptors in the Mouse Amygdala$

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High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

High Resolution Quantitative Synaptic Proteome Profiling of Mouse Brain Regions After Auditory Discrimination Learning

Published on: December 15, 2016

Area of Science:

Neuroscience
Molecular Biology
Proteomics

Background:

Fast excitatory synaptic transmission relies on glutamate and AMPA receptors.
AMPA receptor auxiliary proteins modulate receptor trafficking, localization, and gating.

Purpose of the Study:

To investigate AMPA receptor interactomes in different brain regions.
To identify brain region-specific AMPA receptor subcomplexes and their associated proteins.

Main Methods:

Comprehensive interaction proteomics was used.
AMPA receptor interactomes were analyzed from cortex, hippocampus, and cerebellum.

Main Results:

Distinct AMPA receptor auxiliary protein subcomplexes were identified in a brain region-specific manner.
Interacting proteins can associate with both AMPA and non-AMPA receptor complexes, varying by brain region.

Conclusions:

AMPA receptor auxiliary proteins contribute to brain region-specific regulation of AMPA receptor properties.
The identified subcomplexes offer insights into the differential control of synaptic transmission across the brain.