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Hyperhomocysteinemia in patients with polypoidal choroidal vasculopathy: a case control study
Hui-Chen Cheng1, Jorn-Hon Liu2, Shui-Mei Lee1
1Department of Ophthalmology, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan.
Plos One
|October 23, 2014
Summary
Elevated homocysteine levels are linked to polypoidal choroidal vasculopathy (PCV). This finding suggests hyperhomocysteinemia may contribute to the development of PCV.
Area of Science:
- Ophthalmology
- Vascular Biology
- Biochemistry
Background:
- Polypoidal choroidal vasculopathy (PCV) is a significant cause of vision impairment.
- Elevated plasma homocysteine and serum high sensitivity C-reactive protein (hsCRP) are known vascular disease risk factors.
Purpose of the Study:
- To investigate the association between plasma homocysteine, serum hsCRP levels, and PCV.
- To determine if these biomarkers are risk factors for PCV development.
Main Methods:
- Retrospective case-control study involving 119 PCV patients and 119 controls.
- Measurement of plasma homocysteine and serum hsCRP levels.
- Multivariable logistic regression analysis to assess associations.
Main Results:
- PCV patients had significantly higher median plasma homocysteine levels (12.20 µmol/L vs. 9.80 µmol/L).
- Serum hsCRP levels were slightly higher in the PCV group (0.16 mg/dl vs. 0.11 mg/dl).
- Each 1 µmol/L increase in homocysteine correlated with a 1.54-fold increased likelihood of PCV.
Conclusions:
- Hyperhomocysteinemia is associated with PCV.
- Elevated homocysteine may play a role in the pathogenesis of PCV.
