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Risk of leukemia in first degree relatives of patients with nonsyndromic cleft lip and palate

Eduardo Gonçalves1, Daniella Reis Barbosa Martelli1, Ricardo Della Coletta2

  • 1Universidade Estadual de Montes Claros, Montes Claros, MG, Brazil.

Brazilian Oral Research
|October 23, 2014
PubMed

Insights

This study investigated leukemia in parents of children with nonsyndromic cleft lip and/or palate (NSCL/P). Results show no significant increase in leukemia history among parents of NSCL/P patients compared to controls.

Area of Science:

  • Genetics
  • Pediatrics
  • Oncology

Background:

  • Nonsyndromic cleft lip and/or cleft palate (NSCL/P) are common congenital anomalies.
  • The etiology of NSCL/P is multifactorial, involving genetic and environmental factors.
  • Understanding familial risks for other conditions in NSCL/P families is important.

Purpose of the Study:

  • To determine the frequency of leukemia in parents of patients with NSCL/P.
  • To assess if a family history of leukemia is more common in relatives of NSCL/P patients.

Main Methods:

  • A case-control study design was employed.
  • Evaluated first-degree family members of 358 NSCL/P patients and 1,432 controls.
  • Fisher's exact test was used for statistical analysis.

Main Results:

  • Three parents of NSCL/P patients reported a history of leukemia.
  • Two control subjects had a family history of leukemia.
  • No statistically significant difference in leukemia history was observed between the groups.

Conclusions:

  • The frequency of leukemia in parents of NSCL/P patients is not significantly elevated.
  • This study does not support an increased familial risk of leukemia in NSCL/P kindreds.

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