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First total synthesis of ganglioside DSG-A possessing neuritogenic activity
Yu-Fa Wu1, Yow-Fu Tsai, Jhe-Ruei Guo
1Department of Chemistry, Chung Yuan Christian University, 200 Chung Pei Road, Chung Li, 32023, Taiwan. tsaiyofu@cycu.edu.tw.
Organic & Biomolecular Chemistry
|October 24, 2014
Abstract:
The first total synthesis of ganglioside DSG-A (1) is achieved via chemoselective glycosylation and a [1 + 1 + 2] synthetic strategy. We have also developed an efficient method that can be handled on large scale (50 g) for the synthesis of the phytosphingosine.

