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Clinical applicability of multi-tumor marker protein chips for diagnosing ovarian cancer
Jing Bian1, Bo Li, Xian-Juan Kou
1Department of Laboratory The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China E-mail : shallyvans@163.com, shallyvans@126.com.
Purpose:
To assess the value of multi-tumor marker protein chips in the diagnosis and treatment of ovarian cancer.
Materials And Methods:
Twelve tumor markers (CA19-9, NSE, CEA, CA242, CK19, β-HCG, AFP, SCC, c-PSA, CA125, CA724 and CA15-3) were detected by protein biochip in 220 patients with ovarian carcinomas, 205 with benign ovarian tumors and 200 healthy subjects.
Results:
The positivity rate was obviously higher in ovarian cancer (77.7%), than that in the benign cases (26.3%, p<0.01) and healthy subjects (4.5%, p<0.01). Serum levels of tumor markers were furthermore significantly higher in cases with lymph node metastasis (86.8%) than those without metastasis (44.7%), p<0.01.
Conclusions:
Multi-tumor marker protein chips provide important assistance in the diagnosis and treatment evaluation in ovarian cancers.
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