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Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
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Heart valve stenosis in laser spotlights: insights into a complex disease

Petra Büttner1, Roberta Galli2, Anett Jannasch1

  • 1Faculty of Medicine, TU Dresden, Herzzentrum Dresden, Klinik für Herzchirurgie, Dresden, Germany.

Clinical Hemorheology and Microcirculation
|October 24, 2014
PubMed

Insights

Degenerative heart valve disease research is advanced by a new imaging technique. This method allows detailed, three-dimensional examination of heart valve tissue without extensive processing, offering new insights into disease mechanisms.

Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Cardiovascular Research

Background:

  • Degenerative heart valve disease affects over 3% of adults aged 65+, with valve replacement surgery as the only current therapy.
  • The disease involves structural disorganization and cellular changes in heart valves, with unclear causes and no pharmacological treatments.
  • Current research methods often require extensive processing of excised valve tissue, limiting in-depth analysis.

Purpose of the Study:

  • To introduce a novel, minimally invasive imaging technique for characterizing degenerative heart valve disease.
  • To enable simultaneous, three-dimensional examination of heart valve constituents without extensive sample manipulation.
  • To provide deeper insights into the complex structure and composition of diseased heart valves.

Main Methods:

  • Integration of coherent anti-Stokes Raman scattering (CARS) microscopy.
  • Utilization of endogenous two-photon excited fluorescence (TPEF).
  • Application of second harmonic generation (SHG) imaging.

Main Results:

  • Simultaneous, three-dimensional imaging of cusp constituents was achieved.
  • The novel technique allows examination without extensive sample preparation.
  • Impressive insights into the complex structure of diseased heart valves were obtained.

Conclusions:

  • The combined imaging approach offers a powerful new tool for studying heart valve disease.
  • This technique facilitates a more comprehensive understanding of valve degeneration.
  • It holds potential for advancing research into new therapeutic strategies for heart valve conditions.

Keywords:
Heart valve diseaseaortic valve insufficiencyaortic valve stenosiscoherent anti-Stokes Raman scatteringendogenous two-photon excited fluorescencefibrosisnonlinear optical microscopysecond harmonic generation

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