Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mutilating keratoderma--a case report.

D M Thappa, R Sharma, B Kumar

    Indian Journal of Dermatology
    |March 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Analysis of distribution and localization of proteins of the reelin signalling pathway in mesial temporal lobe epilepsy.

    The International journal of neuroscience·2023
    Same author

    Evaluation of chalcone derivatives for their role as antiparasitic and neuroprotectant in experimentally induced cerebral malaria mouse model.

    3 Biotech·2023
    Same author

    Antimalarial and immunomodulatory potential of chalcone derivatives in experimental model of malaria.

    BMC complementary medicine and therapies·2022
    Same author

    Novel therapeutic mechanism of action of metformin and its nanoformulation in Alzheimer's disease and role of AKT/ERK/GSK pathway.

    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2022
    Same author

    Evaluation of Progesterone Receptor Antagonist and Maxi-K Channel Agonist as Neuroprotective in Feeney's Weight Drop Model of TBI.

    Neurology India·2022
    Same author

    A Rare Case of Dystonia: Leigh-like Syndrome.

    Neurology India·2022
    Same journal

    Severe Irritant Contact Dermatitis to <i>Cyperus Scariosus</i>: A Side Effect of Ayurvedic <i>Plava</i>.

    Indian journal of dermatology·2026
    Same journal

    Extensive Grouped Papules on the Vulva in a Patient with Cervical Cancer.

    Indian journal of dermatology·2026
    Same journal

    Facial Melanosis: A Comprehensive Review of Uncommon and Common Presentations with Personal Experience.

    Indian journal of dermatology·2026
    Same journal

    Exploring AI as a Diagnostic Tool in Medical Imaging for Dermatopathological Diseases.

    Indian journal of dermatology·2026
    Same journal

    Carotid Intima-Media Thickness and Retrobulbar Blood Flow in Patients with Psoriasis.

    Indian journal of dermatology·2026
    Same journal

    Pyoderma Gangrenosum-Like Ulcer Secondary to Antiphospholipid Syndrome.

    Indian journal of dermatology·2026
    See all related articles

    This case study describes a rare genetic skin disorder characterized by severe palmoplantar keratoderma and ichthyosiform dermatosis. The condition, presenting with linear verrucous plaques, appears to have a hereditary component.

    Area of Science:

    • Dermatology
    • Clinical Genetics
    • Rare Diseases

    Background:

    • Palmoplantar keratoderma (PPK) is a group of inherited skin disorders affecting the palms and soles.
    • Ichthyosiform dermatosis encompasses a spectrum of genetic conditions causing dry, scaling skin.
    • The co-occurrence of these conditions suggests a potential shared genetic etiology.

    Observation:

    • A 19-year-old female presented with mutilating palmoplantar keratoderma.
    • She also exhibited generalized ichthyosiform dermatosis.
    • Linear verrucous plaques were noted in the popliteal fossae.

    Findings:

    • The patient's clinical presentation included severe PPK and widespread ichthyosiform scaling.
    • The presence of linear verrucous plaques in flexural areas is a distinctive feature.

    Related Experiment Videos

  • A family history revealed a similar disorder in her mother, suggesting autosomal dominant inheritance.

    • Implications:

    • This case highlights a potentially novel or rare variant of inherited keratoderma and ichthyosis.
    • Further genetic investigation is warranted to identify the causative gene(s).
    • Understanding the genetic basis can aid in diagnosis, genetic counseling, and potential therapeutic strategies for affected families.