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Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs
Published on: December 8, 2010
Development and characterization of arteether-loaded nanostructured lipid carriers for the treatment of malaria
Zulfiqar Ali1, Neeraj Mishra1, Ashish Baldi1
1a Department of Pharmaceutics , ISF College of Pharmacy , Moga , Punjab , India.
Abstract:
The purpose of the present work is to improve the antimalarial activity of the drug arteether (AE) by enhancing its solubility, by loading it into a nanostructured lipid carrier (NLC). The in vitro drug release profile of the NLC showed 93% drug release in 32 h. Complete eradication of the parasite from the blood and efficient anti-malarial pharmacological activity were observed, with the use of AE-loaded NLCs. These results suggest that nanolipid carriers of AE could be a promising carrier system to deliver the poorly soluble antimalarial drug through the oral route, by enhancing its solubility as well as preventing its degradation in the stomach.

