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Updated: Apr 21, 2026

Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens
Published on: April 18, 2013
Cardiac radiology: centenary review
Albert de Roos1, Charles B Higgins
1From the Department of Radiology, Leiden University Medical Center, C2-S, Albinusdreef 2, Leiden, South-Holland 2333 ZA, the Netherlands (A.d.R); and Department of Radiology, University of California-San Francisco, San Francisco, Calif (C.B.H.).
Insights
Cardiac imaging has evolved significantly over the past century, transforming heart disease diagnosis and treatment. Innovations from early angiography to modern CT and MR imaging continue to advance cardiovascular care.
Area of Science:
- Cardiovascular Imaging
- Medical Technology History
Background:
- Cardiac imaging has undergone a century of rapid advancement, significantly impacting the diagnosis and treatment of heart conditions.
- Early techniques like coronary x-ray angiography have paved the way for sophisticated modern modalities.
Observation:
- Many groundbreaking cardiac imaging techniques were initially underappreciated for their clinical potential.
- The clinical adoption of some imaging methods has been lengthy, with ongoing expansion of their applications.
Findings:
- The evolution includes echocardiography, nuclear medicine, cardiac computed tomography (CT), and magnetic resonance (MR).
- Contrast agents in CT and MR imaging are crucial for noninvasively characterizing the myocardium and diagnosing ischemia.
Implications:
- Continuous advancements in cardiac imaging technology enhance our understanding of cardiovascular anatomy and physiology.
- These ongoing developments promise further improvements in noninvasive cardiovascular diagnostics and patient care.
Abstract:
During the past century, cardiac imaging technologies have revolutionized the diagnosis and treatment of acquired and congenital heart disease. Many important contributions to the field of cardiac imaging were initially reported in Radiology. The field developed from the early stages of cardiac imaging, including the use of coronary x-ray angiography and roentgen kymography, to nowadays the widely used echocardiographic, nuclear medicine, cardiac computed tomographic (CT), and magnetic resonance (MR) applications. It is surprising how many of these techniques were not recognized for their potential during their early inception. Some techniques were described in the literature but required many years to enter the clinical arena and presently continue to expand in terms of clinical application. The application of various CT and MR contrast agents for the diagnosis of myocardial ischemia is a case in point, as the utility of contrast agents continues to expand the noninvasive characterization of myocardium. The history of cardiac imaging has included a continuous process of advances in our understanding of the anatomy and physiology of the cardiovascular system, along with advances in imaging technology that continue to the present day.
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