Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Plasma androstanediol glucuronide levels during pregnancy.

J van Droogenbroeck1, A Vermeulen

  • 1Department of Endocrinology, University Hospital, Gent, Belgium.

Clinical Endocrinology
|October 1, 1989
PubMed
Summary

Maternal plasma levels of 5 alpha-androstane-3 alpha, 17 beta-diol glucuronide (ADG) decrease during pregnancy, unlike previous findings. This decrease correlates with reduced dehydroepiandrosterone sulphate (DHEA-S), a key ADG precursor.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Wie zorgt er voor de zorgverlener? Stalking in de ggz blijft onder de radar].

Tijdschrift voor psychiatrie·2026
Same author

Quantification of Angora goat beta chain haemoglobin variants using the Sebia Capillarys 2 Flex-Piercing system.

Journal of the South African Veterinary Association·2026
Same author

Poikilocytosis of Angora goats is associated with erythrocyte density and reticulocytosis.

Journal of the South African Veterinary Association·2023
Same author

Appropriateness of computed tomography and magnetic resonance imaging scans in a rural regional hospital in South Africa: A 6-year follow-up study.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2021
Same author

The fingerprint of the summer 2018 drought in Europe on ground-based atmospheric CO<sub>2</sub> measurements.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences·2020
Same author

Cerebellar progressive multifocal leukoencephalopathy in a patient with a history of Crohn's disease and acute myeloid leukemia.

Acta neurologica Belgica·2019

Area of Science:

  • Endocrinology
  • Reproductive Biology
  • Maternal-Fetal Medicine

Background:

  • Maternal 5 alpha-androstane-3 alpha, 17 beta-diol glucuronide (ADG) levels during pregnancy have been previously reported to increase.
  • Dehydroepiandrosterone sulphate (DHEA-S) is a significant precursor for ADG synthesis.
  • ADG is considered a marker of androgenicity.

Purpose of the Study:

  • To investigate the trend of maternal ADG plasma levels throughout pregnancy.
  • To compare the observed ADG levels with previously reported findings.
  • To explore the relationship between ADG and DHEA-S concentrations during gestation.

Main Methods:

  • Longitudinal monitoring of maternal plasma samples during pregnancy.
  • Quantification of ADG and DHEA-S plasma concentrations using established assays.

Related Experiment Videos

  • Statistical analysis to determine trends and correlations.

    • Main Results:

    • Maternal ADG plasma levels showed a decrease starting from the 10th week of gestation.
    • This observed decrease contrasts with earlier reports of increasing ADG levels.
    • The decline in ADG levels paralleled a concurrent decrease in DHEA-S concentrations.

    Conclusions:

    • The observed decrease in maternal ADG during pregnancy is consistent with the reduction in its precursor, DHEA-S.
    • These findings suggest that ADG levels reflect androgenicity and its modulation during pregnancy.
    • The study provides new insights into the dynamic changes of androgen metabolites in maternal circulation.