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Related Experiment Video

Updated: Apr 21, 2026

Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
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Caseating granulomas in cutaneous leishmaniasis.

Jessica Aoun1, Robert Habib2, Khalil Charaffeddine1

  • 1Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Plos Neglected Tropical Diseases
|October 24, 2014
PubMed
Summary
This summary is machine-generated.

Caseating granulomas are not rare in cutaneous leishmaniasis (CL), found in 18.2% of cases. This highlights CL as a differential diagnosis for caseating granulomas in endemic areas.

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Area of Science:

  • Dermatology
  • Infectious Diseases
  • Pathology

Background:

  • Caseating granulomas are typically associated with tuberculosis (TB).
  • Their presence in cutaneous leishmaniasis (CL) is considered rare.
  • Previous studies lacked large-scale data on the incidence of caseating granulomas in CL.

Purpose of the Study:

  • To determine the incidence of caseating granulomas in a large, multiregional cohort of cutaneous leishmaniasis patients.
  • To investigate the clinical and histopathological characteristics associated with different granuloma types in CL.

Main Methods:

  • A retrospective review of 317 CL patients from Syria, Pakistan, Lebanon, Saudi Arabia, Ethiopia, and Iran.
  • Clinical data (age, sex, duration, lesion type, location) and microscopic data (granuloma type, Ridley's parasitic index and pattern) were collected.
  • Polymerase chain reaction (PCR) confirmed CL and excluded other infections; special stains were used for microorganism detection.

Main Results:

  • Granulomas were present in 61.5% of CL cases; 25.2% of these were caseating granulomas.
  • Caseating granulomas were more frequent in patients from Saudi Arabia (p<0.0001).
  • Histological patterns differed, with caseating granulomas showing higher RP3 (31% vs. 15%) and longer healing times (6.2 vs. 4.0 months).

Conclusions:

  • Cutaneous leishmaniasis (CL) frequently exhibits caseating granulomas (18.2% in this cohort), necessitating its inclusion in the differential diagnosis in endemic regions.
  • CL with caseating granulomas shows a slower healing process, potentially linked to host immune response or parasite virulence.
  • Geographic origin and specific histological patterns are associated with granuloma type in CL.