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Updated: Apr 21, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
Published on: February 14, 2017
Effect of nano-scale curvature on the intrinsic blood coagulation system
Takashi Kushida1, Krishnendu Saha, Chandramouleeswaran Subramani
1Department of Chemistry, University of Massachusetts at Amherst, 710 North Pleasant Street, Amherst, MA 01003, USA. rotello@chem.umass.edu.
Abstract:
The intrinsic coagulation activity of silica nanoparticles strongly depends on their surface curvature. Nanoparticles with higher surface curvature do not denature blood coagulation factor XII on its surface, providing a coagulation 'silent' surface, while nanoparticles with lower surface curvature show denaturation and concomitant coagulation.
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