Multidisciplinary treated thymomas with fatal outcome. A retrospective study

The aim of the study was to assess factors concurring to fatal outcome of patients operated for thymoma with or without myasthenia gravis.

A retrospective observational study was carried out on a series of 10 patients treated for thymoma in the IIIrd Surgical Unit of "St. Spiridon" University Hospital.

Mean survival time was 4.45 years and mortality rate was 38.4%. In 8 patients III and IV Osserman stage myasthenia gravis was associated. 2 patients without myasthenia gravis were diagnosed with a locally advanced stage of thymic carcinoma. According to WHO pathological classification of thymoma, 2 cases were included in type C, those without myasthenia gravis associated and the rest in type B1 (2 cases) and B2 (6 cases). According to Masaoka classification all cases presented invasive thymoma: 6 cases type II, 3 cases type III and one case with type IV. Apart of one case in stage IV, all cases benefitted of complete surgical resection. No perioperative and early postoperative mortality was recorded. On long-term follow-up the cause of death was related to aggravation of myasthenia gravis in 6 cases, to cardiac failure in 2 cases (acute myocardial infarction and constrictive pericarditis) and in 2 cases to metastatic disease (thymoma related death - 20%).

Aggravation of myasthenia gravis was the first cause of death in this series in spite of complete resection and intensive immunosupressive treatment. Completeness of surgical resection is the most important prognostic factor. The histopathological type of thymoma with fatal outcome was type B and C after WHO classification.