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Updated: Apr 21, 2026
An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Protective effect of grape seed extract in experimental menopausal syndrome
Unlabelled:
Grape seed extract (GSE) is a natural product obtained from Vitis vinifera seeds; it has been used as adjuvant therapy in wide range of pathological conditions.
Aim:
In the present study, we investigated the ability of GSE to improve the mental status on ovariectomized rats.
Material And Methods:
GSE (10 mg/kg/day, 60 days long) was administrated orally on ovariectomized adult female rats; then the animals were investigated in open field. Additionally, were measured the hematological parameters, the plasma biochemistry, and the oxidative stress markers.
Results And Discussion:
Treatment of GSE improved the loco motor activity in the open field, the number of crossings were almost twice in GSE treated rats (22.25 +/- 8.75) compared to placebo group (13.00 +/- 2.62) (p < 0.05). Lipid peroxides were reduced up to 51.57% (p < 0.05), while hematology and plasma biochemistry remained almost unchanged.
Conclusion:
GSE improve the mental status and reduced the level of oxidative stress in rats subject to experimental ovariectomy.
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