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Updated: Apr 21, 2026
Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
Functional MRI-guided microsurgery of intracranial arteriovenous malformations: study protocol for a randomised
Bing Zhao1, Yong Cao1, Yuanli Zhao1
1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University; Center of stroke, Beijing institute for brain disorders; Beijing Key Laboratory of Translational Medicine for Cerebraovascular Disease; China National Clinical Research Center for Neurological Diseases, Beijing, China.
This randomized trial investigates functional MRI (fMRI)-guided microsurgery for intracranial arteriovenous malformations (AVMs). It aims to determine if fMRI guidance improves surgical outcomes and patient safety compared to standard microsurgery.
Area of Science:
- Neurosurgery
- Neuroradiology
- Clinical Trials
Background:
- Intracranial arteriovenous malformations (AVMs) present significant morbidity and mortality risks.
- Surgical treatment of AVMs, especially those in eloquent locations, remains high-risk despite advances in microsurgery.
- Functional MRI (fMRI) shows potential for preoperative AVM evaluation in preliminary studies.
Purpose of the Study:
- To evaluate the utility and efficacy of fMRI-guided microsurgery for intracranial AVMs.
- To compare outcomes between standard microsurgery and fMRI-guided microsurgery in a large patient cohort.
- To assess the safety and effectiveness of fMRI-guided AVM treatment.
Main Methods:
- A prospective, randomized controlled clinical trial enrolling 600 patients.
- Patients randomized 1:1 to standard microsurgery or fMRI-guided microsurgery.
- fMRI mapping of eloquent cortex for AVMs in the guided group; outcomes assessed using modified Rankin Scale (mRS) at multiple intervals.
Main Results:
- This section is to be filled after the study is completed and data is analyzed.
Conclusions:
- This section is to be filled after the study is completed and data is analyzed.
