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Development and aging: two opposite but complementary phenomena.

Bruno César Feltes1, Joice de Faria Poloni, Diego Bonatto

  • 1Laboratory of Molecular and Computational Biology, Department of Molecular Biology and Biotechnology, Center of Biotechnology, Federal University of Rio Grande do Sul, Rio Grande do Sul, Brazil.

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Developmental aging theory (DevAge) suggests aging traits arise from evolution. This study used systems biology to find conserved molecular networks linking development and aging in humans and mice.

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Area of Science:

  • Evolutionary biology
  • Gerontology
  • Systems biology

Background:

  • Aging is an evolutionary outcome where developmental traits can lead to aged phenotypes and diseases.
  • The developmental aging theory (DevAge) integrates various age-associated theories.

Purpose of the Study:

  • To investigate developmental and aging-associated molecular networks using systems biology.
  • To compare these networks between human and murine models for evolutionary insights.
  • To provide evidence supporting the DevAge molecular model.

Main Methods:

  • Utilized systems biology tools to analyze developmental and aging networks.
  • Performed evolutionary comparisons between human and murine models.

Main Results:

  • Identified a conserved molecular model coordinating development and aging.
  • Key proteins involved include those related to inflammation, development, epigenetics, and oxygen homeostasis.
  • This mechanism is evolutionarily conserved across mammalian models.

Conclusions:

  • The findings support the developmental aging theory (DevAge) as a unifying molecular model.
  • Inflammation, development, epigenetic mechanisms, and oxygen homeostasis are crucial in linking development and aging.
  • The evolutionary conservation highlights fundamental biological processes.