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Modulating mTOR in aging and health.

Simon C Johnson1, Maya Sangesland, Matt Kaeberlein

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This summary is machine-generated.

Nutrient availability impacts aging and disease through cellular signaling. Reducing mechanistic target of rapamycin (mTOR) activity extends lifespan across species, offering potential therapeutic targets for human aging and disease.

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Area of Science:

  • Cellular and Molecular Biology
  • Geroscience
  • Pharmacology

Background:

  • Physiological responses to nutrient availability are critical in aging and disease.
  • Conserved cellular signaling pathways link nutrient/hormone cues to cellular growth and maintenance.
  • The mechanistic target of rapamycin (mTOR) pathway is a key regulator of aging across diverse organisms.

Purpose of the Study:

  • To highlight the central role of mTOR signaling in aging and age-related diseases.
  • To emphasize the therapeutic potential of targeting mTOR for human healthspan interventions.
  • To review the conserved nature of mTOR in modulating aging from yeast to mammals.

Main Methods:

  • Review of genetic and pharmacological studies on nutrient-sensing pathways.
  • Analysis of conserved cellular signaling mechanisms.
  • Examination of mTOR's role in aging and disease models.
  • Consideration of clinically approved mTOR-targeting agents.

Main Results:

  • Reduced mTOR activity consistently extends lifespan in various organisms, including rodents.
  • mTOR signaling is implicated in a wide spectrum of human diseases.
  • Pharmacological agents targeting mTOR are available for clinical use.

Conclusions:

  • Modulating the mTOR pathway offers promising therapeutic strategies for human aging and disease.
  • Understanding mTOR's role in nutrient sensing is key to developing interventions for healthspan.
  • Targeting mTOR represents a significant avenue for geroscience research and clinical application.