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Updated: Apr 21, 2026
09:53
An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
Published on: August 25, 2017
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Interaction of KSHV with host cell surface receptors and cell entry
Mohanan Valiya Veettil1, Chirosree Bandyopadhyay2, Dipanjan Dutta3
1H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, IL 60064, USA. mohanan.veettil@rosalindfranklin.edu.
Viruses
|October 25, 2014
Summary
Kaposi's sarcoma-associated herpesvirus (KSHV) entry into cells involves complex interactions with host cell receptors like heparan sulfate and EphrinA2. This process dictates specific entry pathways, leading to viral DNA delivery into the nucleus.
Area of Science:
- Virology
- Cell Biology
- Molecular Biology
Background:
- Kaposi's sarcoma-associated herpesvirus (KSHV) entry is crucial for infection.
- Understanding KSHV entry mechanisms is key to developing antiviral strategies.
- KSHV exhibits broad cell tropism, utilizing diverse cellular receptors.
Purpose of the Study:
- To review the principal mechanisms of KSHV cell entry.
- To elucidate the role of host cell surface receptors in KSHV attachment and entry.
- To discuss how KSHV modulates host cell signaling for viral entry.
Main Methods:
- Review of existing literature on KSHV entry pathways.
- Analysis of KSHV interactions with cell surface molecules (heparan sulfate, integrins, EphrinA2).
- Examination of endocytic pathways (clathrin-mediated endocytosis, macropinocytosis) utilized by KSHV.
Main Results:
- KSHV utilizes heparan sulfate, integrins, and EphrinA2 for cell attachment and entry.
- Distinct entry pathways are employed depending on the target cell type (e.g., fibroblasts vs. endothelial cells).
- Viral entry triggers host cell signaling cascades essential for subsequent infection stages.
Conclusions:
- KSHV entry is a sophisticated, multi-step process dependent on specific receptor-ligand interactions.
- Cell type-specific entry mechanisms highlight the virus's adaptability.
- Modulation of host cell signaling is critical for successful KSHV internalization and nuclear delivery of viral DNA.
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