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Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing
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Detection of Targetable Alterations in Non-small Cell Lung Cancer using Next-generation Sequencing

Published on: October 10, 2025

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[Advances of driver gene and targeted therapy of non-small cell lung cancer]

Dan Zhang1, Yan Huang2, Hongyang Wang2

  • 1Department of Postgraduate, Hebei United University, Tangshan 063009, China.

Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer
|October 25, 2014
PubMed

Insights

Targeted therapy revolutionizes lung cancer treatment by focusing on specific driver gene mutations. This review covers 11 key driver genes and their targeted therapies for non-small cell lung cancer (NSCLC).

Area of Science:

  • Oncology
  • Genetics
  • Pharmacology

Context:

  • Lung cancer remains a leading global cause of cancer mortality.
  • Advances in molecular biology have identified specific "driver" gene mutations in tumors.
  • This has shifted cancer treatment from a "one-size-fits-all" approach to personalized medicine.

Purpose:

  • To review the functional and structural characteristics of 11 key driver genes in non-small cell lung cancer (NSCLC).
  • To discuss the targeted therapies associated with these driver gene mutations.
  • To highlight the revolutionary impact of targeted therapy in NSCLC treatment.

Summary:

  • The discovery of driver genes has enabled targeted therapies, transforming non-small cell lung cancer (NSCLC) treatment.
  • This review examines 11 driver genes identified by the Society of Clinical Oncology (ASCO).
  • It details their characteristics and the corresponding targeted therapeutic strategies.

Impact:

  • Targeted therapies offer visible and effective treatment outcomes for NSCLC patients.
  • Personalized medicine based on driver gene mutations represents a paradigm shift in oncology.
  • This approach improves treatment efficacy and patient prognosis in lung cancer.

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