Fixed drug eruption to propofol

We present a case of fixed drug eruption to propofol following a series of sedations of a patient for a number of day case procedures. The patient experienced oedema and blistering of his penis, increasing in severity and duration following each subsequent exposure. The diagnosis was confirmed by punch biopsy following an intravenous challenge test with propofol. Whilst reports of fixed drug eruptions to anaesthetic induction agents are uncommon, a number of drugs used commonly by anaesthetists are known triggers. We discuss fixed drug eruptions in relation to anaesthetic practice, aiming to raise awareness of this adverse drug reaction.