The human endonexin II (ENX2) gene is located at 4q28----q32
W S Modi1, H N Seuànez, M Jaye
1Biological Carcinogenesis and Development Program, Program Resources Inc., NCI-Frederick Cancer Research Facility, MD 21701.
Cytogenetics and Cell Genetics
|January 1, 1989
Summary
Researchers identified the endonexin II gene (ENX2) location on chromosome 4. This annexin gene family member
Area of Science:
- Molecular biology
- Genetics
- Cell biology
Background:
- The annexin gene family comprises structurally similar, calcium-dependent phospholipid-binding proteins.
- The precise functions of the known annexin genes remain largely undetermined.
- Previous studies localized a lipocortin II gene, another annexin, to chromosome 4's long arm.
Purpose of the Study:
- To determine the chromosomal location of the endonexin II gene (ENX2).
- To contribute to the understanding of annexin gene family organization and function.
Main Methods:
- Southern transfer analysis using human x rodent somatic cell hybrids.
- In situ chromosome hybridization.
Main Results:
- The endonexin II gene (ENX2) was assigned to the 4q28-q32 region of chromosome 4.
- This finding aligns with the previous localization of a lipocortin II gene to the same chromosome arm.
Conclusions:
- The chromosomal localization of ENX2 provides a basis for further functional studies.
- The data suggest potential co-localization or related functions of annexin family members on chromosome 4.
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