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Updated: Apr 21, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
Cutaneous melanoma in 1-year-old child: an insight on infantile melanoma
Fadwa J Altaf1, Sherine I Salama, Abdullah S Bawazer
1Departments of Pathology, and Plastic Surgery, King Abdulaziz University, Jeddah, Saudi Arabia.
Insights
Pediatric malignant melanoma (MM) is rare but requires careful diagnosis. This case highlights the diagnostic challenges of congenital pigmented lesions in infants, emphasizing the need for clinical correlation.
Area of Science:
- Pediatric Oncology
- Dermatopathology
Background:
- Malignant melanoma (MM) is exceptionally rare in pediatric populations.
- Accurate diagnosis necessitates meticulous pathological evaluation and clinical correlation.
Observation:
- A 12-month-old female presented with a congenital pigmented lesion.
- The lesion exhibited changes in size and shape since birth.
Findings:
- The case presented diagnostic challenges for malignant melanoma (MM) in an infant.
- Differential diagnoses for congenital pigmented lesions were considered.
Implications:
- This case underscores the importance of considering rare pediatric malignancies.
- Highlights the diagnostic complexities in pediatric dermatology and oncology.
Abstract:
In the past, malignant melanoma (MM) is a diagnosis of unheard in children, but nowadays MM is a very rare malignancy in children. Its diagnosis requires careful interpretation of the pathological diagnostic criteria with clinical correlation of the findings. In this study, the authors are presenting a pigmented lesion in a 12-month-old girl, which was present since her birth with increase in size and shape. The authors discussed the difficulty that confronted them in making a diagnosis of MM and the differential diagnosis.
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