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Association of the renal resistive index with microvascular complications in type 2 diabetic subjects

N D Ozmen1, U Mousa2, Y Aydin3

  • 1Burhan Nalbantoglu Hospital, Department of Internal Medicine, Nicosia, Cyprus.

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [And] German Diabetes Association
|October 25, 2014
PubMed

Insights

The intrarenal resistive index (RI) may predict microvascular complications in Type 2 Diabetes Mellitus patients. Higher RI values correlate with increased urinary albumin excretion and the presence of retinopathy and neuropathy.

Area of Science:

  • Nephrology
  • Endocrinology
  • Radiology

Background:

  • Chronic complications significantly contribute to morbidity and mortality in diabetic populations.
  • Intrarenal resistive index (RI) elevation is noted in hypertensive individuals with microalbuminuria, but data for diabetic subjects is limited.

Purpose of the Study:

  • To investigate the association between intrarenal RI and urinary albumin excretion (UAE) in Type 2 Diabetes Mellitus (T2DM).
  • To determine if intrarenal RI can predict microvascular complications in diabetic patients.

Main Methods:

  • A study involving 101 T2DM subjects categorized by UAE levels (Group 1: <30 mg/day, Group 2: 30-300 mg/day, Group 3: >300 mg/day).
  • Subjects were also grouped by intrarenal RI (Group I: ≥0.70, Group II: <0.70).
  • Statistical analysis compared RI values, diabetes duration, hip circumference, hs-CRP levels, and the prevalence of retinopathy and neuropathy across groups.

Main Results:

  • Mean intrarenal RI was significantly higher in Group 3 (UAE >300 mg/day) compared to Groups 1 and 2.
  • Higher intrarenal RI (≥0.70) was associated with longer diabetes duration, increased hip circumference, and elevated hs-CRP levels.
  • The presence of retinopathy and neuropathy was significantly higher in subjects with intrarenal RI ≥0.70.

Conclusions:

  • Intrarenal RI is elevated in T2DM patients with higher levels of albuminuria.
  • Intrarenal RI may serve as a predictor for the development of microvascular complications, including retinopathy and neuropathy, in diabetic individuals.

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