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Related Concept Videos

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Related Experiment Video

Updated: Apr 21, 2026

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
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Cancer theranostics with gold nanoshells.

Jun Zhao1, Michael Wallace, Marites P Melancon

  • 1Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

Nanomedicine (London, England)
|October 25, 2014
PubMed
Summary

Gold nanoshells (AuNSs) offer tunable near-infrared light absorption for targeted cancer therapy. Their light-to-heat conversion and nanobubble formation enable precise tumor destruction with minimal damage to healthy tissues.

Keywords:
cancer imagingdrug deliverygold nanoshellshyperthermiaphotoacousticsiRNAsurface plasmon resonancethermal ablationtumor penetrationtumor targeting

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Area of Science:

  • Biomedical Engineering
  • Nanoscience
  • Nanotechnology

Background:

  • Gold nanoshells (AuNSs) are nanoparticles with tunable surface plasmon resonance.
  • Their properties can be optimized for near-infrared (NIR) light absorption, enabling deep tissue penetration.

Purpose of the Study:

  • To describe the physicochemical properties of AuNSs for cancer theranostics.
  • To explore the design, preparation, and application of AuNSs in oncology.

Main Methods:

  • Utilizing AuNSs' tunable surface plasmon resonance for NIR light absorption.
  • Leveraging AuNSs' efficient light-to-heat conversion for thermal ablation.
  • Investigating nanobubble formation for mechanical cell disruption.
  • Exploring AuNSs as platforms for drug and diagnostic agent delivery.

Main Results:

  • AuNSs demonstrate efficient light-to-heat conversion upon laser irradiation, inducing thermal damage to tumors.
  • Transient nanobubbles around AuNSs create mechanical stress, selectively damaging tumor cells.
  • AuNSs serve as versatile carriers for theranostic agents.

Conclusions:

  • AuNSs show significant promise in cancer theranostics due to their unique optical and physical properties.
  • Further research and development are needed to overcome challenges for successful clinical translation.