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The mononuclear phagocyte colony-stimulating factor (CSF-1, M-CSF)
1Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Hematology/Oncology Clinics of North America
|September 1, 1989
Abstract:
The macrophage colony-stimulating factor-1 (CSF-1, M-CSF) induces the proliferation and supports the survival of mononuclear phagocytes and mediates its pleiotropic actions by binding to cell surface receptors encoded by the c-fms proto-oncogene. The structure, biologic activities, and therapeutic potential of CSF-1 and the role of its receptor in signal transduction in normal and transformed cells are discussed.