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Updated: Apr 21, 2026

Evaluation of Tumor-infiltrating Leukocyte Subsets in a Subcutaneous Tumor Model
Published on: April 13, 2015
Phenotypically and functionally distinct T-cell subsets in anti-tumor responses
1Department of Oncogenesis, Institute for Cancer Research, Osaka University Medical School, 1-1-50, Fukushima, Fukushima-ku, 553, Japan.
Abstract:
Helper T cells and cytolytic T cells have both been implicated in tumor cell rejection in vivo but their roles and relative importance are still controversial. Here, Toshiyuki Hamaoka and Hiromi Fujiwara discuss recent experiments which suggest that tumor cell growth can be inhibited nonspecifically by the action of gamma interferon as well as by cytolysis and that immunized cells of both 'cytotoxic cell' and 'helper cell' phenotype can produce this lymphokine.
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