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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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What are Proteins?01:55

What are Proteins?

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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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[Preface for special issue on proteomics (2014)].

Fude Fang, Youhe Gao

    Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
    |October 28, 2014
    PubMed
    Summary

    This special issue reviews proteomics research, covering diverse species and advanced techniques like mass spectrometry. It explores proteome applications in areas from spider toxins to disease research.

    Area of Science:

    • Proteomics as a key functional genomics discipline in the post-genomic era.
    • Interdisciplinary nature of proteomics, integrating medical biology, chemistry, physics, and information science.

    Background:

    • This special issue compiles reviews and original papers on proteomics research progress.
    • Focuses on identifying challenges, exploring applications, and forecasting future development in the field.

    Discussion:

    • Covers proteomics across various species, including humans, mammals, prokaryotes, and actinobacteria.
    • Details proteomics methodologies and techniques such as tandem mass spectrometry, urine protein preservation, quantitative proteomic analysis, and meta-analysis.

    Key Insights:

    • Examines diverse proteome functions and applications, including spider toxins, protein phosphorylation, oocytes, early embryos, liver fibrosis, and drug-resistant tuberculosis.

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    Outlook:

    • Highlights the critical role of proteomics in advancing biological and medical sciences.
    • Emphasizes the need for continued research and technological innovation in proteomics.