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[The products of class II histocompatibility complex (IC or IA+IE) restrict the interaction between specific
1Institute of Immunology, Academy of Medical Sciences of the USSR, Moscow.
Spleen T cells of mice which were i.v. immunized with large dose of irradiated allogeneic lymphocytes inhibit donor alloantigen-activated DNA synthesis in mixed lymphocyte culture. To assure suppressor function, specific suppressor T cells (SSTC) both need to contact an antigen and ought to interact with responder T lymphocyte as well. Such an interaction is restricted in MHC class II genes: in IA + IE complex or in IC. IJ sub-region product present on the SSTC is not involved into the suppressor-responder interaction. By shielding of the SSTC markers with poly- and monoclonal antibodies to IC, IA and IE molecules, it is shown that two variants of suppression restriction are due to the respective SSTC sub-populations: only one of them bears ICd determinant, while both possess IAk and IEk antigens. The functions of SSTC sub-populations and their connection with immune response "interactional restriction" are discussed.
Spleen T cells of mice which were i.v. immunized with large dose of irradiated allogeneic lymphocytes inhibit donor alloantigen-activated DNA synthesis in mixed lymphocyte culture. To assure suppressor function, specific suppressor T cells (SSTC) both need to contact an antigen and ought to interact with responder T lymphocyte as well. Such an interaction is restricted in MHC class II genes: in IA + IE complex or in IC. IJ sub-region product present on the SSTC is not involved into the suppressor-responder interaction. By shielding of the SSTC markers with poly- and monoclonal antibodies to IC, IA and IE molecules, it is shown that two variants of suppression restriction are due to the respective SSTC sub-populations: only one of them bears ICd determinant, while both possess IAk and IEk antigens. The functions of SSTC sub-populations and their connection with immune response "interactional restriction" are discussed.