Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

17
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
17
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

1.4K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.4K
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

1.1K
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
1.1K
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

25
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
25
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

21
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
21
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

891
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
891

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparison of the Color Doppler Vascularity Index in Patients with Pancreatic Adenocarcinoma and Chronic Pancreatitis from a Single Center in Poland.

Medical science monitor : international medical journal of experimental and clinical research·2022
Same author

Dynamic Doppler Ultrasound Assessment of Tissue Perfusion Is a Better Tool than a Single Vessel Doppler Examination in Differentiating Malignant and Inflammatory Pancreatic Lesions.

Diagnostics (Basel, Switzerland)·2021
Same author

Diabetic kidney disease: Are the reported associations with single-nucleotide polymorphisms disease-specific?

World journal of diabetes·2021
Same author

Application of the Molecular Adsorbent Recirculating System in Type 1 Hepatorenal Syndrome in the Course of Alcohol-Related Acute on Chronic Liver Failure.

Medical science monitor : international medical journal of experimental and clinical research·2020
Same author

Doppler tissue perfusion measurement is a sensitive and specific tool for a differentiation between malignant and inflammatory pancreatic tumors.

PloS one·2019
Same author

Left Ventricular Strain and Relaxation Are Independently Associated with Renal Cortical Perfusion in Hypertensive Patients.

Advances in experimental medicine and biology·2018

Related Experiment Video

Updated: Apr 21, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

3.5K

[Groove pancreatitis--case report].

Przemysław Dyrla, Cezary Adamiec, Jerzy Gil

    Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
    |October 28, 2014
    PubMed
    Summary

    Groove pancreatitis, a rare chronic pancreatitis subtype, often affects middle-aged men. Surgical intervention is recommended for persistent symptoms and uncertain diagnoses when conservative treatments fail.

    Area of Science:

    • Gastroenterology
    • Pathology

    Background:

    • Groove pancreatitis is an uncommon form of chronic pancreatitis, typically affecting middle-aged men with a history of smoking and alcohol abuse.
    • This case highlights a male patient with recurrent abdominal pain and vomiting, initially diagnosed with chronic pancreatitis.

    Observation:

    • The patient presented with recurrent symptoms despite conservative management including pain relief, antibiotics, and nutritional support.
    • Despite initial success, conservative therapy provided only short-term relief, necessitating further investigation.

    Findings:

    • Histopathological examination of the pancreatoduodenectomy specimen revealed focal chronic inflammation and fibrosis in the pancreatic head, involving the duodenum.
    • Accurate diagnosis required multiple tests, with histopathology proving crucial in identifying groove pancreatitis.

    More Related Videos

    Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
    07:38

    Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

    Published on: May 10, 2024

    1.6K
    An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation
    06:28

    An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

    Published on: October 31, 2025

    612

    Related Experiment Videos

    Last Updated: Apr 21, 2026

    Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
    06:35

    Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

    Published on: June 28, 2021

    3.5K
    Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
    07:38

    Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

    Published on: May 10, 2024

    1.6K
    An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation
    06:28

    An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

    Published on: October 31, 2025

    612

    Implications:

    • Careful diagnosis is essential to differentiate groove pancreatitis from pancreatic cancer, which shares similar symptoms.
    • Surgical treatment, such as pancreatoduodenectomy, is indicated for cases with frequent recurrences, short-term improvement, or diagnostic uncertainty.