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[Anomalies in thyroid function in children with trisomy 21].

C Stoll1, Y Alembik, B Dott

  • 1Institut de Puériculture, Centre Hospitalo-Universitaire, Strasbourg, France.

Journal De Genetique Humaine
|December 1, 1989
PubMed
Summary

Children with Down syndrome (DS) show abnormal thyroid function, with higher thyroid stimulating hormone (TSH) and lower reverse T3 (rT3) levels compared to healthy children.

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Area of Science:

  • Endocrinology
  • Pediatrics
  • Genetics

Context:

  • Down syndrome (DS) is associated with various health complications, including potential thyroid dysfunction.
  • Thyroid hormone levels are critical for normal growth and development in children.

Purpose:

  • To investigate and characterize thyroid function abnormalities in children with Down syndrome.
  • To compare thyroid hormone profiles between children with DS and age-matched controls.

Summary:

  • Serum concentrations of ultra-sensitive thyroid stimulating hormone (TSH), free T4, free T3, total T4, total T3, and reverse T3 (rT3) were measured in 60 children with DS (aged 3 months to 16 years) and matched controls.
  • Children with DS exhibited significantly increased TSH levels and decreased rT3 concentrations compared to controls.
  • The ratio of rT3 to TSH was also significantly lower in the DS group, indicating altered thyroid hormone metabolism.

Impact:

  • These findings highlight specific thyroid function alterations in children with Down syndrome.
  • Understanding these differences is crucial for monitoring and managing potential endocrine health issues in this population.
  • Suggests the need for targeted thyroid screening protocols in pediatric Down syndrome care.

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