Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anatomy of the Circulatory System02:03

Anatomy of the Circulatory System

88.2K
The human circulatory system consists of blood, blood vessels that carry blood away from the heart, around the body, and back to the heart, and the heart itself, which acts as a central pump. The systemic circuit supplies blood to the whole body, the coronary circuit supplies blood to the heart, and the pulmonary circuit supplies blood flow between the heart and lungs.
88.2K
Open and closed-loop control systems01:17

Open and closed-loop control systems

1.9K
Control systems are foundational elements in automation and engineering. They are broadly categorized into open-loop and closed-loop systems. These classifications hinge on the presence or absence of feedback mechanisms, significantly influencing the system's performance, complexity, and application.
An open-loop control system operates without feedback from the output. It consists of two primary elements: the controller and the controlled process. The controller receives an input signal...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety-enhanced optimal control of turbodynamic blood pumps.

Artificial organs·2011
Same author

Experimental verification of the feasibility of the cardiovascular impedance simulator.

IEEE transactions on bio-medical engineering·2009
Same author

Application of extremum seeking control to turbodynamic blood pumps.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2007
Same author

In vitro evaluation of multiobjective hemodynamic control of a heart-assist pump.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2005

Related Experiment Video

Updated: Apr 21, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

6.1K

Model-referenced cardiovascular circulatory simulator: construction and control.

Kwan-Woong Gwak1

  • 1Department of Mechanical Engineering, Sejong University, Seoul, Korea.

Artificial Organs
|October 28, 2014
PubMed
Summary
This summary is machine-generated.

A new cardiovascular circulatory simulator (CCS) was developed using a model-referenced approach for enhanced physiological accuracy. This innovative simulator accurately replicates cardiovascular system behavior across diverse conditions, overcoming limitations of previous methods.

Keywords:
Cardiovascular circulatory simulatorElastanceFluidic element modelingPhysiological fidelity

More Related Videos

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.1K
Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

3.6K

Related Experiment Videos

Last Updated: Apr 21, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

6.1K
In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

2.1K
Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

3.6K

Area of Science:

  • Biomedical Engineering
  • Physiology
  • Medical Devices

Background:

  • Physiological feasibility is critical for cardiovascular circulatory simulators (CCSs).
  • Previous CCS validation methods using limited human data restrict fidelity assessment across varied physiological states.
  • A need exists for CCS validation methods applicable to a wide range of body conditions.

Purpose of the Study:

  • To develop and validate a novel model-referenced cardiovascular circulatory simulator.
  • To ensure the simulator's physiological fidelity is well-established and verifiable.
  • To create a CCS capable of responding to diverse physiological conditions.

Main Methods:

  • Implemented an electrical-analog model of the cardiovascular system as a reference.
  • Replicated the reference model in a hardware simulator using fluidic element modeling.
  • Utilized feedback control of a mock ventricle to achieve model-reproducing behavior.

Main Results:

  • The proposed simulator demonstrated a strong correlation with the reference electrical-analog model's behavior.
  • Physiological validity of the simulator was successfully verified through comparison with the established model.
  • The simulator exhibited responsiveness to various simulated body conditions.

Conclusions:

  • The developed model-referenced CCS achieves high physiological fidelity.
  • This approach overcomes the limitations of validating CCSs against specific, limited human datasets.
  • This represents the first in vitro CCS verified for consistency with a well-established reference model's behavior.