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Updated: Apr 21, 2026
Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
Cyclophosphamide/fludarabine nonmyeloablative allotransplant for acute myeloid leukemia
Muhammad Rizwan Khawaja1, Susan M Perkins, Jennifer E Schwartz
1Division of Hematology/Oncology, Department of Medicine, Indiana University School of Medicine, Melvin and Bren Simon Cancer Center, Indianapolis, Indiana.
Abstract:
We compared survival outcomes following myeloablative allotransplant (MAT) or cyclophosphamide/fludarabine (Cy/Flu) nonmyeloablative allotransplant (NMAT) for 165 patients with acute myelogenous leukemia (AML) in remission or without frank relapse. Patients who received NMAT were more likely to be older and have secondary AML and lower performance status. At a median follow-up of 61 months, median event-free survival and overall survival survival were not different between NMAT and MAT in univariate as well as multivariate analyses. Cy/Flu NMAT may provide similar disease control and survival when compared with MAT in patients with AML in remission or without frank relapse.
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