Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epigenetic Regulation01:37

Epigenetic Regulation

3.3K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
3.3K
Epigenetic Regulation01:46

Epigenetic Regulation

28.5K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
28.5K
Epigenetic Regulation01:46

Epigenetic Regulation

23.9K
23.9K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

6.0K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
6.0K
Histone Modification02:32

Histone Modification

14.3K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
14.3K
Histone Modification02:32

Histone Modification

4.0K
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

RNA Pol-II transcripts in nucleolar associated domains of cancer cell nucleoli.

Nucleus (Austin, Tex.)·2025
Same author

The Myc-associated zinc finger protein epigenetically controls expression of interferon-γ-stimulated genes by recruiting STAT1 to chromatin.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

The RNA helicases DDX5 and DDX17 facilitate neural differentiation of human pluripotent stem cells NTERA2.

Life sciences·2022
Same author

Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects.

Nature communications·2021
Same author

The Myc-associated zinc finger protein (MAZ) works together with CTCF to control cohesin positioning and genome organization.

Proceedings of the National Academy of Sciences of the United States of America·2021
Same author

DNA·RNA triple helix formation can function as a <i>cis</i>-acting regulatory mechanism at the human <i>β-globin</i> locus.

Proceedings of the National Academy of Sciences of the United States of America·2019
Same journal

"Wouldn't It Be Easier to Be Burned at the Stake?": Schizophrenia and Deinstitutionalization in <i>Bitter Medicine</i>.

Perspectives in biology and medicine·2026
Same journal

The Mental Health Crisis of Rural America: Understanding Supply and Demand.

Perspectives in biology and medicine·2026
Same journal

The Final Act of Care: Accuracy in Cause of Death Statements.

Perspectives in biology and medicine·2026
Same journal

Existential Competence: Redefining Clinical Excellence Beyond Health Optimization.

Perspectives in biology and medicine·2026
Same journal

Making Fun of Medicine: Resisting Medicine's Principalities.

Perspectives in biology and medicine·2026
Same journal

Courage, Conviction, Resolve: The Story of Dr. Gui Xi'en.

Perspectives in biology and medicine·2026
See all related articles

Related Experiment Video

Updated: Apr 21, 2026

Methylated DNA Immunoprecipitation
21:24

Methylated DNA Immunoprecipitation

Published on: January 2, 2009

23.4K

The evolution of epigenetics.

Gary Felsenfeld

    Perspectives in Biology and Medicine
    |October 28, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Epigenetics explores how organisms develop without altering DNA. This research examines DNA methylation and histone modifications, clarifying their roles in cell development and gene expression patterns.

    More Related Videos

    An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
    10:41

    An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

    Published on: April 5, 2018

    10.0K
    Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
    05:55

    Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

    Published on: June 17, 2025

    910

    Related Experiment Videos

    Last Updated: Apr 21, 2026

    Methylated DNA Immunoprecipitation
    21:24

    Methylated DNA Immunoprecipitation

    Published on: January 2, 2009

    23.4K
    An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
    10:41

    An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

    Published on: April 5, 2018

    10.0K
    Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
    05:55

    Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization

    Published on: June 17, 2025

    910

    Area of Science:

    • Developmental Biology
    • Molecular Biology
    • Genetics

    Background:

    • Early embryology questioned how a single cell forms a complex organism.
    • Epigenetics initially studied these developmental processes.
    • The definition evolved to encompass heritable traits without DNA sequence changes.

    Purpose of the Study:

    • To clarify the definition and mechanisms of epigenetics.
    • To investigate the roles of DNA methylation and histone modifications in development.
    • To resolve confusion regarding epigenetic marks and transcriptional machinery.

    Main Methods:

    • Review of early embryological studies.
    • Analysis of historical definitions of epigenetics.
    • Examination of research on DNA methylation.
    • Investigation of histone modifications as epigenetic carriers.
    • Discussion of the role of histones in gene expression.

    Main Results:

    • Epigenetics definition shifted from developmental processes to heritable phenotype transmission.
    • DNA methylation was an early focus, with recent emphasis on histone modifications.
    • Confusion exists regarding modifications that maintain gene expression versus those in the transcriptional apparatus.

    Conclusions:

    • Re-evaluation of the definition of epigenetics is necessary.
    • Understanding histone modifications is crucial for defining epigenetic inheritance.
    • Clarifying these mechanisms is key to understanding cell-type-specific gene expression.