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Related Concept Videos

Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

11
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
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Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

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Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
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Related Experiment Video

Updated: Apr 21, 2026

Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion
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Long-term outcome after spinal cord infarctions.

S R Hanson1, F Romi, T Rekand

  • 1Department of Neurology, Haukeland University Hospital, Bergen, Norway.

Acta Neurologica Scandinavica
|October 28, 2014
PubMed
Summary
This summary is machine-generated.

Spinal cord infarction patients show improved long-term outcomes with lower mortality but worse function compared to cerebral infarction patients. Re-employment rates were higher in spinal cord infarction survivors.

Keywords:
cerebrovascular diseasesquality of lifespinal cord disorders

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Area of Science:

  • Neurology
  • Vascular Neurology
  • Rehabilitation Medicine

Background:

  • Spontaneous spinal cord infarction (SCI) is a rare condition with limited data on long-term patient outcomes.
  • Understanding the long-term prognosis of SCI is crucial for patient management and rehabilitation strategies.

Purpose of the Study:

  • To investigate the long-term outcomes of patients who experienced spontaneous spinal cord infarction.
  • To compare the long-term outcomes of SCI patients with those of patients who suffered cerebral infarction.

Main Methods:

  • A cohort of 30 patients with SCI discharged between 1995 and 2010 was studied.
  • Surviving patients completed questionnaires assessing employment, function, mood, fatigue, pain, and quality of life.
  • Data were compared to a control group of patients with cerebral infarction.

Main Results:

  • Mortality in SCI patients was associated with poor acute-phase functioning.
  • Thirteen of 20 responding SCI patients could walk at follow-up.
  • Compared to cerebral infarction patients, SCI patients had lower mortality, poorer function, higher re-employment rates, and more pain.

Conclusions:

  • Many patients with SCI experience significant functional improvement over the long term.
  • Despite worse functional outcomes, SCI is associated with lower mortality and higher re-employment rates than cerebral infarction.